Description
Recombinant full-length human DYRK2 was expressed in E Coli cells using an N-terminal GST tag. The gene accession number is NM_006482.
DYRK2 (also known as dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2) belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development and is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 expressed in E Coli demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro (1). DYRK2 also regulates p53 to induce apoptosis in response to DNA damage (2)